Meredith and Shepperd face each other off as professionals for the first time. A couple has to choose between operating on the husband’s tumor and extend his life for the price of his personality and memories, or leave the tumor alone and have a few more real years together. While this is happening, George feels a little emasculated from living with two girls who look at him more as a sister than a desirable member of the opposite sex. Finally, Izzie is furious at Alex for making numerous copies of an advertisement she did for lingerie.